Xiang-Mei Wu and Qiu-Xian ShenPages 668-673 (6)
The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.
Palladium, copper, iron, arylation, arylboronic acid.
Department of Chemistry, College of Science, Lishui University, Lishui, Zhejiang 323000, China.